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KMID : 0043320170400060695
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Archives of Pharmacal Research
2017 Volume.40 No. 6 p.695 ~ p.703
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Synthesis and anti-inflammatory activities of novel dihydropyranoaurone derivatives
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Wang Zheng
Bae Eun-Ju
Han Young-Taek
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Abstract
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A novel series of dihydropyranoaurone derivatives were synthesized and evaluated as potential anti-inflammatory agents. Late-stage derivatization by versatile piperazine-catalyzed aldol reaction between dihydropyanobenzofuran intermediate 2 and diverse aldehydes readily afforded the novel dihydropyranoaurone analogs. Evaluation of the synthesized dihydropyranoaurone derivatives and related compounds regarding their inhibiting inducible nitric oxide synthase and nitrite production of lipopolysaccaride-stimulated RAW 264.7 cells provided insight into the structure?activity relationship of aurone derivatives.
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KEYWORD
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Dihydropyranoaurone, Synthesis, Late-stage derivatization, Aldol reaction, Nitric oxide, Anti-inflammation
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